Aldose Reductase Gene and Stroke Risk in Diabetic Patients
Author Information
Author(s): Watarai A, Nakashima E, Hamada Y, Watanabe G, Naruse K, Miwa K, Kobayashi Y, Kamiya H, Nakae M, Hamajima N, Sekido Y, Niwa T, Oiso Y, Nakamura J
Primary Institution: Nagoya University Graduate School of Medicine
Hypothesis
Does the C-106T polymorphism of the aldose reductase gene determine susceptibility to diabetic macroangiopathy in Type 2 diabetic patients?
Conclusion
The CT or TT genotype of the aldose reductase gene is associated with an increased risk of stroke in Type 2 diabetic patients.
Supporting Evidence
- The CT + TT genotype and T allele were significantly more frequent in patients with stroke.
- Erythrocyte AR protein content was higher in patients with the CT and TT genotypes.
- After adjusting for various factors, the association between the AR genotype and stroke remained significant.
Takeaway
This study found that certain genetic variations in a gene related to sugar metabolism can make people with diabetes more likely to have a stroke.
Methodology
Genotyping of the C-106T polymorphism and measurement of AR protein content in erythrocytes using ELISA.
Potential Biases
Potential bias due to the exclusion of certain patient groups and reliance on self-reported medical histories.
Limitations
The study was limited to a single marker of the AR gene and did not explore other potential polymorphisms.
Participant Demographics
378 Type 2 diabetic patients (210 men and 168 women) aged 28–88 years.
Statistical Information
P-Value
0.019
Confidence Interval
1.15–5.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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