The Role of p53 Gene Variation in Cervical Adenocarcinomas
Author Information
Author(s): Andersson S, Rylander E, Strand A, Sällström J, Wilander E
Primary Institution: Huddinge University Hospital
Hypothesis
Is the p53 codon 72 polymorphism a risk factor for cervical adenocarcinomas?
Conclusion
Women with the arg/arg genotype of the p53 gene are at a higher risk for cervical adenocarcinomas, but this risk is not related to HPV infection.
Supporting Evidence
- The study found that 71% of invasive adenocarcinomas had the arg/arg genotype compared to 47% in controls.
- HPV DNA was found in 86 of the tumors analyzed.
Takeaway
This study found that a specific gene variation can make women more likely to develop a type of cervical cancer, but it doesn't seem to be connected to a common virus that also affects the cervix.
Methodology
The study analyzed 111 cases of cervical adenocarcinoma and 188 control samples for p53 codon 72 polymorphism using PCR and SSCP techniques.
Participant Demographics
The study included females with cervical adenocarcinoma and controls with normal cytology.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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