Oxidative Metabolites of Diisononyl Phthalate as Biomarkers for Human Exposure Assessment
Author Information
Author(s): Manori J. Silva, John A. Reidy, James L. Preau Jr., Larry L. Needham, Antonia M. Calafat
Primary Institution: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention
Hypothesis
Can oxidative metabolites of diisononyl phthalate (DINP) serve as better biomarkers for human exposure assessment than the traditional monoisononyl phthalate (MINP)?
Conclusion
The study found that oxidative metabolites of DINP are more reliable biomarkers for assessing human exposure than MINP.
Supporting Evidence
- MINP was not detected in any of the urine samples analyzed.
- MCIOP, MHINP, and MOINP were detected in 97%, 100%, and 87% of the urine samples, respectively.
- The geometric mean concentrations of the oxidative metabolites were 8.6, 11.4, and 1.2 ng/mL.
Takeaway
This study looked at how much of a chemical called DINP is in people's urine. It found that new markers are better for checking if people have been exposed to DINP than the old ones.
Methodology
Urinary concentrations of MINP and three oxidative metabolites (MCIOP, MHINP, MOINP) were measured in urine samples from 129 adults with no known DINP exposure.
Limitations
The study did not assess the effects of DINP exposure on human health.
Participant Demographics
129 U.S. adults of both sexes with no documented exposure to DINP.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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