Comparing Malaria Treatments in Mali
Author Information
Author(s): Kayentao Kassoum, Maiga Hamma, Newman Robert D, McMorrow Meredith L, Hoppe Annett, Yattara Oumar, Traore Hamidou, Kone Younoussou, Guirou Etienne A, Saye Renion, Traore Boubacar, Djimde Abdoulaye, Doumbo Ogobara K
Primary Institution: Malaria Research and Training Centre, University of Bamako
Hypothesis
The combination of amodiaquine plus sulphadoxine-pyrimethamine (AQ+SP) would be efficacious for treating uncomplicated malaria in children.
Conclusion
The combination of AQ+SP provides a potentially low-cost alternative for treatment of uncomplicated P. falciparum infection in Mali and appears to have the added value of longer protective effect against new infections.
Supporting Evidence
- 397 children were enrolled and followed for 28 days.
- ACPR rates were 55.7%, 90.8%, and 97.7% for AS+AQ, AS+SP, and AQ+SP respectively before PCR correction.
- After PCR correction, ACPR rates were > 95% for all treatment groups.
Takeaway
This study tested different malaria treatments on children and found that one combination worked really well and could be cheaper for families.
Methodology
A randomized open-label trial comparing three oral antimalarial combinations in children aged 6 to 59 months.
Potential Biases
Potential bias in treatment allocation as participants were not informed of the drug received.
Limitations
The study was conducted in a single rural location, which may limit generalizability.
Participant Demographics
Children aged 6 to 59 months, primarily of the Bambara ethnic group.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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