Basil Seed Mucilage as a Bioadhesive Polymer for Naproxen Sodium Delivery
Author Information
Author(s): Tripathi Devika, Rathour Krislay, Pandey Prashant, Tiwari Ritesh Kumar, Rai Awani Kumar
Primary Institution: PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur, India
Hypothesis
Can basil seed mucilage enhance the solubility and delivery of naproxen sodium when used in microsphere and suppository formulations?
Conclusion
Basil seed mucilage significantly improves the bioadhesive properties and solubility of naproxen sodium in rectal drug delivery systems.
Supporting Evidence
- Basil seed mucilage showed excellent mucoadhesive qualities in ex-vivo assays.
- The optimized formulation OBMF5 achieved a drug release of 88.7% after 7 hours.
- Encapsulation efficiency improved with higher basil/alginate ratios.
- Particle size analysis revealed microspheres ranging from 456 to 712 μm.
Takeaway
This study shows that a natural substance from basil seeds can help medicine dissolve better and stick to the inside of the body, making it easier to take.
Methodology
Microspheres were created using a double emulsion solvent evaporation technique, and their properties were evaluated through various analyses including particle size, encapsulation efficiency, and drug release studies.
Limitations
Further studies are needed to fully understand the safety and toxicity of basil seed mucilage.
Statistical Information
P-Value
0.0141
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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