Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers
1999
Low Tumour Cell Proliferation and Poor Prognosis in Colorectal Cancer
Sample size: 56
publication
Evidence: moderate
Author Information
Author(s): Palmqvist R, Sellberg P, Öberg Å, Tavelin B, Rutegård J N, Stenling R
Primary Institution: Umeå University, Umeå, Sweden
Hypothesis
Does systematic spatial heterogeneity in tumour cell proliferation affect survival in Dukes' stage B colorectal cancers?
Conclusion
Tumours with low proliferation at the invasive margin have a poorer prognosis.
Supporting Evidence
- Proliferative activity was significantly higher at the luminal border compared to the invasive margin.
- Low proliferation at the invasive margin was linked to poorer prognosis in both univariate and multivariate analyses.
Takeaway
If cancer cells grow slowly at the edge of a tumour, it might mean the patient will not do well.
Methodology
Morphometric quantification of Ki-67 expression at the luminal border and invasive margin in colorectal cancers.
Participant Demographics
Dukes' stage B colorectal cancer patients.
Statistical Information
P-Value
P = 0.014 (univariate), P = 0.042 (multivariate)
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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