LRRCE: A Unique Capping Motif in Chordates
Author Information
Author(s): Park Hosil, Huxley-Jones Julie, Boot-Handford Ray P, Bishop Paul N, Attwood Teresa K, Bella Jordi
Primary Institution: Wellcome Trust Centre for Cell-Matrix Research, University of Manchester
Hypothesis
Is the LRRCE motif a common structural feature found in other leucine-rich repeat proteins?
Conclusion
The LRRCE motif is exclusive to the SLRP family and provides insights into early vertebrate evolution.
Supporting Evidence
- The LRRCE motif is not found in non-chordate genomes.
- The motif appears to have evolved during early chordate evolution.
- The expanded list of SLRP members provides insights into vertebrate evolution.
- The LRRCE motif can be used as a tool for identifying new SLRP sequences.
Takeaway
The LRRCE motif is a special part of certain proteins that helps scientists understand how these proteins evolved in animals like fish and mammals.
Methodology
Genome-wide searches were conducted using defined sequence patterns to identify LRRCE motifs in proteins.
Limitations
Some sequences were from incomplete genome assemblies, and the findings should be considered preliminary.
Digital Object Identifier (DOI)
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