Functional Genomics in Chickens: Microarrays and Gene Pathways
Author Information
Author(s): L. A. Cogburn, X. Wang, W. Carre, L. Rejto, S. E. Aggrey, M. J. Duclos, J. Simon, T. E. Porter
Primary Institution: University of Delaware
Hypothesis
The study aims to develop integrated-systems microarrays for transcriptional profiling and to discover regulatory pathways in chickens.
Conclusion
The study successfully generated a large number of expressed sequence tags and developed microarrays that will enhance the understanding of chicken genomics.
Supporting Evidence
- The consortium generated 30,609 expressed sequence tags (ESTs) and developed several chicken DNA microarrays.
- Initial studies revealed that gene expression profiles in liver are significantly altered by metabolic perturbations.
- Transcriptional profiling across multiple tissues will help construct a detailed genetic blueprint for chicken growth and development.
Takeaway
Researchers are trying to understand how chicken genes work together by creating special tools to look at many genes at once.
Methodology
The study involved high-throughput sequencing of chicken cDNA libraries and the development of various chicken DNA microarrays.
Digital Object Identifier (DOI)
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