Discovery of a Distinct Superfamily of Kunitz-Type Toxin (KTT) from Tarantulas
2008
Correction of Errors in Kunitz-Type Toxin Study
Sample size: 5
publication
Author Information
Author(s): Yuan Chun-Hua He, Quan-Yuan Peng, Kuan Diao, Jian-Bo Jiang, Li-Ping Tang, Xing Liang, Song-Ping
Conclusion
The corrected text clarifies the effects of HWTX-XI on potassium currents in rat DRG neurons and X. laevis oocytes.
Supporting Evidence
- 1 µM HWTX-XI reduced potassium currents in rat DRG neurons by 41.7%.
- 5 µM HWTX-XI reduced potassium currents in X. laevis oocytes.
- At 10 µM, HWTX-XI produced rapid inhibition that was reversible.
Takeaway
This study fixes some mistakes about how a toxin affects nerve cells, showing it can reduce potassium currents.
Digital Object Identifier (DOI)
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