CD3-ζ Expression in Cervical Cancer
Author Information
Author(s): de Gruijl T D, Bontkes H J, Peccatori F, Gallee M P W, Helmerhorst Th J M, Verheijen R H M, Aarbiou J, Mulder W M C, Walboomers J M M, Meijer C J L M, van de Vange N, Scheper R J
Primary Institution: European Cancer Centre/Amsterdam Gynaecologic Oncology Group
Hypothesis
The study investigates the expression of CD3-ζ on T-cells in cervical carcinoma and its relation to lymph node metastasis.
Conclusion
The study found that CD3-ζ expression is frequently reduced in T-cells within cervical cancer lesions.
Supporting Evidence
- CD3-ζ expression was reduced in seven cervical cancer cases and strongly reduced in 17 cases.
- In control sections, CD3-ɛ and CD3-ζ were co-expressed in almost equal numbers.
- Both tumour-negative and -positive lymph nodes showed ζ chain expression equal to that of CD3-ɛ.
Takeaway
In cervical cancer, the immune cells often don't work well because they have less of a certain important protein called CD3-ζ.
Methodology
The study involved immunostaining of paraffin-embedded or snap-frozen sections from cervical cancer specimens and lymph nodes.
Digital Object Identifier (DOI)
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