Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours
1999
Study of LKB1 Gene in Ovarian Tumours
Sample size: 49
publication
Evidence: moderate
Author Information
Author(s): Wang Z-J, Churchman M, Campbell I G, Xu W-H, Yan Z-Y, McCluggage W G, Foulkes W D, Tomlinson I P M
Primary Institution: Tumour Genetics Group, Nuffield Department of Clinical Medicine, University of Oxford
Hypothesis
Is LKB1 a candidate tumour suppressor gene for sporadic ovarian tumours?
Conclusion
LKB1 mutations are rare in ovarian tumours, but allele loss on 19p13.3 suggests involvement of a different gene.
Supporting Evidence
- Allele loss at the marker D19S886 was found in 24% of sporadic ovarian adenocarcinomas.
- Two mutations were detected in one granulosa cell tumour, indicating some genetic changes.
Takeaway
The study looked at a gene called LKB1 in ovarian cancer and found that while it can cause cancer when inherited, it doesn't usually change in the cancer itself.
Methodology
The study screened ovarian cancers for allele loss and somatic mutations in the LKB1 gene.
Digital Object Identifier (DOI)
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