Drugs That Cause Low Blood Pressure
Author Information
Author(s): Sari Nurunnisa, Jaehde Ulrich, Wermund Anna Maria
Primary Institution: Institute for Medical Information Processing, Biometry and Epidemiology ‐ IBE LMU Munich
Hypothesis
What drugs have been associated with hypotension in adults and what type of evidence supports these associations?
Conclusion
This review provides a comprehensive overview of antihypertensive and nonantihypertensive drugs that induce hypotension.
Supporting Evidence
- 26 antihypertensive drugs were identified across nine classes.
- 158 other drugs were associated with hypotension.
- Common antihypertensive classes included ACE inhibitors, beta blockers, and diuretics.
- Nonantihypertensive classes included neuroleptics, alpha-1 blockers, and opioids.
Takeaway
Some medicines can make your blood pressure too low, which can be dangerous. This study looked at many different medicines to see which ones can cause this problem.
Methodology
A systematic literature search was conducted using MEDLINE, Embase, and Cochrane Library, focusing on studies from January 2013 to May 2023.
Potential Biases
Observational studies may be susceptible to confounding factors, including age-related issues.
Limitations
The review did not focus on dose-dependence of antihypertensive effects or the role of drug-drug interactions.
Participant Demographics
Many studies focused on older patients, often with comorbidities.
Digital Object Identifier (DOI)
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