Microaneurysm Size in Residual Edema After Faricimab Injection for Diabetic Macular Edema
Author Information
Author(s): Yamada Yutaka, Takamura Yoshihiro, Morioka Masakazu, Oshima Hideyuki, Gozawa Makoto, Matsumura Takehiro, Inatani Masaru
Primary Institution: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Japan
Hypothesis
This study aimed to clarify the morphological characteristics of microaneurysms in residual edema following consecutive faricimab injections.
Conclusion
The residual areas following three doses of faricimab displayed a higher microaneurysm density, less microaneurysm loss, and a high density of large-sized microaneurysms compared to the absorbed areas.
Supporting Evidence
- 8 out of 42 patients showed residual edema after treatment.
- The density of microaneurysms was significantly higher in residual edema areas.
- Large-sized microaneurysms were more prevalent in residual edema areas.
- Microaneurysm turnover was significantly lower in residual areas compared to absorbed areas.
Takeaway
The study found that after treatment for diabetic eye disease, some patients still had swollen areas with many large blood vessel problems, which might mean their treatment isn't working as well.
Methodology
A retrospective analysis of 42 eyes from patients with diabetic macular edema who received three monthly injections of faricimab was conducted, focusing on the turnover of microaneurysms in residual and absorbed edema areas.
Limitations
The study's retrospective nature and the small number of patients with residual edema limit the findings.
Participant Demographics
{"age":"65.1 ± 8.8","gender":{"male":27,"female":13},"duration_of_diabetes":"8.8 ± 7.5 years"}
Statistical Information
P-Value
p = 0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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