IgE Recognition Patterns of Panallergens in Allergic Patients
Author Information
Author(s): Scala Enrico, Alessandri Claudia, Palazzo Paola, Pomponi Debora, Liso Marina, Bernardi Maria Livia, Ferrara Rosetta, Zennaro Danila, Santoro Mario, Rasi Chiara, Mari Adriano
Primary Institution: Center for Molecular Allergology, IDI-IRCCS, Rome, Italy
Hypothesis
The study aims to analyze the IgE recognition profile of three groups of panallergens in allergic patients.
Conclusion
The study found that a significant majority of patients produce specific IgE to one group of panallergens but not to others.
Supporting Evidence
- 1,521 patients were reactive to profilins, 1,420 to PR-10, and 632 to tropomyosins.
- 2,688 patients recognized only one out of the three distinct groups of molecules.
- A significant direct relationship between different representative molecules within each group of panallergens was found.
Takeaway
The study looked at how allergic patients react to different allergens and found that most people are allergic to just one type of allergen.
Methodology
The study used the Immuno-Solid phase Allergen Chip (ISAC) microarray system to evaluate IgE recognition profiles.
Potential Biases
Potential bias in patient selection as the study focused on individuals with a history of allergic conditions.
Limitations
The study population was limited to individuals from Italy, which may affect the generalizability of the results.
Participant Demographics
The study included 3,113 individuals, 49.9% female, with ages ranging from 2 to 96 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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