Lymphotoxin-alpha Polymorphisms and Cancer Risk in Autopsy Cases
Author Information
Author(s): Takei Kako, Ikeda Shinobu, Arai Tomio, Tanaka Noriko, Muramatsu Masaaki, Sawabe Motoji
Primary Institution: Tokyo Medical and Dental University
Hypothesis
Do LTA polymorphisms influence the presence of cancer?
Conclusion
The study found some evidence of an association between LTA polymorphisms and cancer risk in elderly Japanese men.
Supporting Evidence
- The presence of cancer was higher in males than in females.
- C804A polymorphism was associated with lower cancer presence in males.
- T495C polymorphism was associated with higher gastric cancer presence in males.
Takeaway
This study looked at whether certain genetic variations are linked to cancer in older men. It found that some variations might lower the risk of lung cancer.
Methodology
LTA polymorphisms were determined in 1,536 autopsy cases, and tumors were reviewed and assessed in relation to LTA genotype.
Potential Biases
Selection bias may arise from the chance of admission, consent to autopsy, and cause of death.
Limitations
The study was hospital-based, which may introduce selection bias, and had limited access to lifestyle information.
Participant Demographics
The study included 827 males and 709 females, with a mean age of 80 years.
Statistical Information
P-Value
0.05
Confidence Interval
95% CI = 0.53 – 0.99
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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