Increased Frequency of the S Allele in Non-Hodgkin's Lymphoma
Author Information
Author(s): P.E. Crossen, M.J. Morrison, B.M. Coils
Primary Institution: Christchurch Hospital, Christchurch, New Zealand
Hypothesis
Is the S allele of the L-myc oncogene associated with susceptibility to non-Hodgkin's lymphoma?
Conclusion
The S allele occurs more frequently in non-Hodgkin's lymphoma patients, suggesting a link to susceptibility.
Supporting Evidence
- The S allele was found to occur more frequently in non-Hodgkin's lymphoma patients compared to controls.
- Previous studies have linked the S allele to increased susceptibility to various cancers.
- The study confirms earlier findings regarding the association of the S allele with non-Hodgkin's lymphoma.
Takeaway
This study found that a specific gene variant is more common in people with a type of cancer called non-Hodgkin's lymphoma.
Methodology
The study compared the frequency of the S allele in 100 non-Hodgkin's lymphoma patients, 44 Hodgkin's disease patients, and 100 healthy controls using DNA analysis.
Limitations
Statistical analysis was not attempted for subgroups due to insufficient sample sizes.
Participant Demographics
100 NHL patients (53 men, 47 women) aged 19-88; 44 HD patients (23 men, 21 women) aged 15-83; 100 controls (50 men, 50 women) aged 18-75, all of European descent.
Statistical Information
P-Value
0.032
Statistical Significance
p=0.032
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