Predictors of Local Recurrence in Duct Carcinoma In Situ
Author Information
Author(s): P. Price, H.D. Sinnett, B. Gusterson, G. Walsh, R.P. A'Hern, J.A. McKinna
Primary Institution: Institute of Cancer Research; The Royal Marsden Hospital
Hypothesis
What factors predict local recurrence and progression in patients with duct carcinoma in situ treated by surgery alone?
Conclusion
Conservative surgery may be inadequate for treating duct carcinoma in situ, as it carries a high risk of local recurrence and progression to invasive disease.
Supporting Evidence
- 26 out of 60 patients (43%) experienced local recurrence.
- The estimated proportion recurrence-free at 7 years was 59%.
- Patients treated with conservative surgery were 4.71 times more likely to have local recurrence.
- Local excision alone resulted in a 55% local recurrence rate at 7 years.
- 14 out of 26 patients who recurred locally developed invasive disease.
Takeaway
This study looked at women with a type of breast cancer called duct carcinoma in situ and found that those who had less aggressive surgery were more likely to have their cancer come back.
Methodology
Retrospective analysis of 60 patients treated by surgery alone for duct carcinoma in situ, with follow-up through clinical examination and mammography.
Potential Biases
Potential selection bias due to non-randomized treatment choices.
Limitations
The study was not randomized and relied on historical data from a specific time period.
Participant Demographics
Patients treated between 1972 and 1982, median age 54 years.
Statistical Information
P-Value
0.001 and 0.03
Confidence Interval
95% CI 46-72%
Statistical Significance
p<0.05
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