Prognostic Factors in Recurrent Breast Cancer
Author Information
Author(s): G. Blanco, K. Holli, M. Heikkinen, O.-P. Kallioniemi, P. Taskinen
Primary Institution: Oulu University Central Hospital and Tampere University Hospital, Finland
Hypothesis
What are the prognostic factors that influence the behavior of recurrences in breast cancer?
Conclusion
Histological grading, site of recurrence, and disease-free interval are significant prognostic variables in recurrent breast cancer.
Supporting Evidence
- Patients with soft tissue recurrences had a median survival of 32 months, while those with visceral recurrences had a median survival of 12 months.
- ER-positive patients survived longer than ER-negative patients regardless of the site of recurrence.
- The disease-free interval is significantly related to survival outcomes.
Takeaway
This study looked at breast cancer patients who had recurrences and found that where the cancer comes back and how long the patient was free of cancer before it returned can help predict how well they will do.
Methodology
The study analyzed 613 cases of primary breast cancer with known estrogen and progesterone receptor determinations and complete follow-up.
Limitations
The study excluded bilateral and male breast cancer patients, and the number of cases for some variables was unequal.
Participant Demographics
The study included female patients with histologically verified primary mammary carcinomas.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
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