Risk of Angiosarcoma After Breast Cancer
Author Information
Author(s): Cozen W, Bernstein L, Wang F, Press M F, Mack T M
Primary Institution: University of Southern California School of Medicine
Hypothesis
Does a history of invasive breast cancer increase the risk of developing angiosarcoma?
Conclusion
Women with a history of breast cancer have a significantly increased risk of developing angiosarcoma in the upper extremity and chest.
Supporting Evidence
- A history of breast cancer increased the risk of upper extremity angiosarcoma by more than 59-fold.
- The odds ratio for angiosarcoma of the chest and breast was 11.6.
- Other sarcomas of the chest and breast also showed increased risk.
Takeaway
If a woman has had breast cancer, she is much more likely to get a rare type of cancer called angiosarcoma in her arm or chest.
Methodology
A case-control study comparing women with angiosarcoma to those with other cancers.
Potential Biases
Potential selection bias in choosing controls.
Limitations
The study is limited to a specific population and time frame.
Participant Demographics
Females aged 25 and older diagnosed with angiosarcoma in Los Angeles County.
Statistical Information
Confidence Interval
95% CI = 21.9–152.8
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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