Introducing SBML-SAT: A Tool for Sensitivity Analysis in Systems Biology
Author Information
Author(s): Zi Zhike, Zheng Yanan, Rundell Ann E, Klipp Edda
Primary Institution: Max Planck Institute for Molecular Genetics
Hypothesis
SBML-SAT aims to automate sensitivity analysis for various systems biology models.
Conclusion
SBML-SAT provides the community of systems biologists a new tool for the analysis of their SBML models of biochemical and cellular processes.
Supporting Evidence
- SBML-SAT allows for global sensitivity analysis, which is not supported by existing SBML software.
- The software can handle models with discontinuous events, expanding its applicability.
- SBML-SAT provides a user-friendly graphical interface for running various analyses.
Takeaway
SBML-SAT is a new software that helps scientists understand how changes in their biological models affect the results, making it easier to analyze complex systems.
Methodology
The software implements algorithms for simulation, steady state analysis, robustness analysis, and both local and global sensitivity analysis for SBML models.
Limitations
The software does not include a SBML model editor and does not support delay differential equations.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website