The Role of Apoptosis in Transplantation and Autoimmunity
Author Information
Author(s): ALICE LI, OKECHUKWU OJOGHO, ALAN ESCHER
Primary Institution: Loma Linda University & Medical Center
Hypothesis
Can the induction of apoptosis be used to modulate immune responses in transplantation and autoimmune diseases?
Conclusion
Apoptotic cells can induce tolerance and potentially improve outcomes in transplantation and autoimmune diseases.
Supporting Evidence
- Apoptotic cells can induce tolerance through their processing by dendritic cells.
- Regulatory T cells can be expanded through the infusion of apoptotic cells.
- Induction of apoptosis can prevent or treat autoimmune diseases in animal models.
- Mixed chimerism can be established through the infusion of apoptotic cells.
- Apoptotic cells can modulate immune responses and improve transplant outcomes.
Takeaway
When cells die, they can help the body learn to ignore them, which is important for preventing rejection of transplants and treating autoimmune diseases.
Methodology
The review discusses various studies on the effects of apoptotic cells on immune responses, particularly focusing on dendritic cells and regulatory T cells.
Limitations
The review does not provide original experimental data and relies on existing literature, which may have varying methodologies and results.
Digital Object Identifier (DOI)
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