Breast Cancer in Patients Aged 80 and Older: Survival and Treatment Insights
Author Information
Author(s): Gambini Donatella, Veronesi Valentina, Despini Luca, Ferrero Stefano, Rossi Claudia, Garrone Ornella, Rigoni Marta, Muti Paola Cornelia Maria, Runza Letterio, Kuhn Elisabetta
Primary Institution: Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Hypothesis
What are the survival outcomes and treatment challenges for patients diagnosed with invasive breast carcinoma at 80 years and older?
Conclusion
The study found that about half of the patients were still alive after 8.5 years, highlighting the need for tailored management strategies for elderly breast cancer patients.
Supporting Evidence
- 84.1% of patients did not have advanced disease at diagnosis.
- 69.3% of patients underwent surgical treatment.
- 81.8% received systemic therapy.
- 25.6% experienced disease progression after 5 years.
- 82.9% overall survival probability at 5 years.
Takeaway
This study looked at older people with breast cancer and found that many can live a long time after diagnosis, but they need special care because they are often frail.
Methodology
A prospective observational study was conducted on 88 patients aged 80 and older diagnosed with invasive breast cancer, focusing on survival outcomes and treatment strategies.
Potential Biases
Potential bias due to the high dropout rate and the exclusion of patients who were lost to follow-up.
Limitations
The study had a small sample size and a high dropout rate, which may affect the reliability of the findings.
Participant Demographics
All participants were aged 80 years or older, with a mean age of 84.5 years; 97.7% were female.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 71.3–95.3%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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