NHHR as a Predictor of CKD Risk in NAFLD Patients
Author Information
Author(s): Fan Yong-Qiang, Wang Hao, Wang Pei-Pei, Shi Zhi-Yong, Wang Yan, Xu Jun
Primary Institution: Liver Transplantation Center, The First Hospital of Shanxi Medical University, Taiyuan, China
Hypothesis
There would be a strong association between the NHHR and the risk of developing CKD in NAFLD patients.
Conclusion
In patients with non-fibrotic NAFLD, a significantly elevated NHHR is closely associated with an increased risk of CKD.
Supporting Evidence
- In NAFLD subjects without liver fibrosis, the highest tertile of NHHR was inversely related to eGFR.
- NHHR was positively related to CKD in NAFLD subjects without liver fibrosis.
- The study utilized data from a large national health survey (NHANES).
- Subgroup analyses showed consistent results across various demographics.
Takeaway
This study found that a specific cholesterol ratio can help predict kidney problems in people with fatty liver disease.
Methodology
Data from NHANES 2017-2020 was analyzed using weighted multivariate linear regression and logistic regression.
Potential Biases
Potential biases from missing self-reported data in NHANES.
Limitations
The study is cross-sectional and may not establish causality; liver fibrosis assessment was not based on biopsies.
Participant Demographics
Average age of 49.26 years, 56.99% male, majority Non-Hispanic White (62.84%).
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: −3.97, −0.32
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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