How Nitric Oxide Affects Lung Inflammation Through Surfactant Protein D
Author Information
Author(s): Guo Chang-Jiang, Atochina-Vasserman Elena N, Abramova Elena, Foley Joseph P, Zaman Aisha, Crouch Erika, Beers Michael F, Savani Rashmin C, Gow Andrew J
Primary Institution: Rutgers, The State University of New Jersey
Hypothesis
Nitric oxide controls the pro- and anti-inflammatory functions of surfactant protein D by altering its quaternary structure via S-nitrosylation.
Conclusion
S-nitrosylation of surfactant protein D alters its structure and enhances its pro-inflammatory signaling in the lungs.
Supporting Evidence
- S-nitrosylation of SP-D leads to its structural alteration and enhances its inflammatory signaling.
- SNO-SP-D is shown to induce macrophage chemotaxis.
- The study demonstrates that S-nitrosylation occurs both in vitro and in vivo.
Takeaway
Nitric oxide can change a lung protein called surfactant protein D, making it help fight infections instead of just keeping inflammation in check.
Methodology
The study involved in vitro and in vivo experiments to assess the effects of S-nitrosylation on surfactant protein D and its role in macrophage chemotaxis.
Limitations
The study does not address the effects of other potential nitrosylated proteins in the BAL fluid.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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