How CCR6+ Tregs Help Tumors Grow
Author Information
Author(s): Xu Lin, Xu Wei, Wen Zhenke, Xiong Sidong
Primary Institution: Soochow University, Shanghai Medical College of Fudan University, Zunyi Medical College
Hypothesis
The study investigates the mechanism behind the enrichment of CCR6+ regulatory T cells (Tregs) in tumor mass during breast cancer progression.
Conclusion
CCR6+ Tregs are enriched in tumor mass due to their prior in situ proliferation, which is triggered by tumor-resident dendritic cells in a TGF-β dependent manner.
Supporting Evidence
- CCR6+ Tregs were found to proliferate more than CCR6− Tregs in tumor mass.
- Tumor-resident dendritic cells were shown to promote the proliferation of CCR6+ Tregs.
- Adoptive transfer of CCR6+ Tregs inhibited CD8+ T cell function more effectively than CCR6− Tregs.
Takeaway
In tumors, a special type of immune cell called CCR6+ Tregs grows more than others, helping the tumor avoid being attacked by the body's defenses.
Methodology
The study used flow cytometry to analyze Tregs in a murine breast cancer model, assessing their proliferation and frequency in tumor infiltrating lymphocytes.
Participant Demographics
Female Balb/c mice and Balb/c nude mice, 5–6 weeks of age.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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