Genetic Variant Linked to Wilms Tumor Risk in Children
Author Information
Author(s): Luo Ming, Wang Yizhen, Yin Huimin, Zhou Chunlei, Lu Hongting, Zhou Haixia, He Shaohua, He Jing, Zhu Jinhong, Zhang Shouhua
Primary Institution: Jiangxi Provincial Children's Hospital
Hypothesis
Is the miR-196a2 rs11614913 T>C polymorphism associated with Wilms tumor susceptibility in children?
Conclusion
The study found that the miR-196a2 rs11614913 T>C polymorphism is associated with an increased risk of Wilms tumor in Chinese children.
Supporting Evidence
- The study included 416 Wilms tumor patients and 936 healthy controls.
- The rs11614913 C allele was linked to increased Wilms tumor risk in various genetic models.
- The association was significant in children older than 18 months and those with advanced tumor stages.
Takeaway
A specific genetic change can make some kids more likely to get a type of kidney cancer called Wilms tumor.
Methodology
The study analyzed the genotypes of miR-196a2 rs11614913 in 416 Wilms tumor patients and 936 healthy controls using TaqMan technology and logistic regression.
Potential Biases
Potential sampling bias and confounding factors due to the retrospective nature of the study.
Limitations
The sample size was moderate, only one SNP was studied, and environmental factors were not accounted for.
Participant Demographics
Chinese Han children, with 416 cases of Wilms tumor and 936 matched healthy controls.
Statistical Information
P-Value
0.007
Confidence Interval
1.14-2.21
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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