Effect of Taxus baccata Leaves Extract on Asthma in Experimental Animals
Author Information
Author(s): Patel PK, Patel KV
Primary Institution: C. K. Pithawalla Institute of Pharmaceutical Science and Research
Hypothesis
The study investigates the bronchodilating effect and bronchial hyperreactivity of alcoholic extract of Taxus baccata leaves in experimental animals.
Conclusion
The alcoholic extract of Taxus baccata leaves significantly reduces bronchoconstriction and bronchial hyperreactivity in guinea pigs.
Supporting Evidence
- Treatment with AET showed significant protection against bronchospasm induced by histamine and acetylcholine.
- AET decreased total leukocyte and differential leukocyte counts in bronchoalveolar lavage fluid.
- AET protected against mast cell disruption induced by compound 48/80.
Takeaway
This study shows that a plant called Taxus baccata can help make it easier to breathe for animals with asthma.
Methodology
The study used guinea pigs to test the effects of Taxus baccata leaves extract on induced bronchospasm and bronchial hyperreactivity.
Limitations
The study was conducted only on guinea pigs, which may limit the applicability of the results to humans.
Participant Demographics
Wistar rats and guinea pigs of either sex, aged and weight specified.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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