Rfam 15: RNA families database in 2025
Author Information
Author(s): Ontiveros-Palacios Nancy, Cooke Emma, Nawrocki Eric P, Triebel Sandra, Marz Manja, Rivas Elena, Griffiths-Jones Sam, Petrov Anton I, Bateman Alex, Sweeney Blake
Primary Institution: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
Conclusion
The Rfam database has significantly expanded its coverage and improved the quality of RNA family annotations.
Supporting Evidence
- The Rfam database now includes 26,106 genomes, a 76% increase from previous versions.
- 65 RNA families were enhanced using experimentally determined 3D structures.
- Gene Ontology term coverage increased to 75% of families.
- 14 new Hepatitis C Virus RNA families were added.
Takeaway
Rfam is like a big library for tiny RNA families, and it just got a lot bigger and better at helping scientists understand them.
Methodology
The Rfam database was updated with new genomes, improved RNA family structures using 3D models, and enhanced annotations.
Limitations
Some families may still lack sufficient data or have outdated annotations.
Digital Object Identifier (DOI)
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