Tumour Marker Antigens During Menses and Pregnancy
Author Information
Author(s): Y. Touitou, Y. Darbois, A. Bogdan, A. Auzeby, S. Keusseoglou
Primary Institution: Department of Biochemistry, Faculte de Medecine Pitie-Salpetriere
Hypothesis
How do tumour marker plasma concentrations vary during pregnancy and menstruation?
Conclusion
CA-15.3 and SCC plasma concentrations increase significantly during pregnancy, while CA-19.9 is sensitive to benign diseases.
Supporting Evidence
- CA-15.3 and SCC plasma concentrations increased significantly during pregnancy.
- 10% of pregnant women had abnormally high CA-19.9 plasma concentrations.
- CA-125 levels were elevated in some pregnant women, confirming previous studies.
Takeaway
This study looked at blood tests for cancer markers in pregnant women and found some markers can be higher during pregnancy, but that doesn't always mean there's cancer.
Methodology
A transverse study was conducted on 100 pregnant women and 22 young women at two stages of their menstrual cycle, measuring various tumour markers in blood samples.
Limitations
The study did not account for all possible benign conditions that could affect tumour marker levels.
Participant Demographics
100 pregnant women (mean age 29.2) and 22 young women (mean age 21.8).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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