Radiotherapy for Large Benign Skull Base Meningiomas
Author Information
Author(s): Giuseppe Minniti, Enrico Clarke, Luigi Cavallo, Mattia Falchetto Osti, Vincenzo Esposito, Gianpaolo Cantore, Paolo Cappabianca, Riccardo Maurizi Enrici
Primary Institution: Department of Radiation Oncology, Sant' Andrea Hospital, Università degli Studi di Roma 'La Sapienza'
Hypothesis
To assess the safety and efficacy of fractionated stereotactic radiotherapy (FSRT) for large skull base meningiomas.
Conclusion
FSRT is a suitable treatment for large skull base meningiomas, providing high local control rates comparable to conventional radiotherapy.
Supporting Evidence
- The 3-year and 5-year progression-free survival rates were 96% and 93%, respectively.
- Survival was 100% at the time of analysis.
- Hypopituitarism occurred in 19% of patients as a late complication.
Takeaway
Doctors used a special type of radiation therapy to treat big tumors in the brain, and it worked really well for most patients.
Methodology
Fifty-two patients were treated with FSRT, receiving a total dose of 50 Gy in 30 fractions over 6 weeks.
Limitations
The follow-up period was relatively short, and longer follow-up is needed to assess long-term efficacy and toxicity.
Participant Demographics
17 males and 35 females, median age 56 years (range 34-74 years).
Statistical Information
P-Value
p = 0.16
Digital Object Identifier (DOI)
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