SEAS: A System for SEED-Based Pathway Enrichment Analysis
2011
SEAS: A System for Pathway Enrichment Analysis
Sample size: 42
publication
Evidence: moderate
Author Information
Author(s): Mao Xizeng, Zhang Yu, Xu Ying, Brusic Vladimir
Primary Institution: University of Georgia
Hypothesis
Can the SEAS tool effectively analyze pathway enrichment for bacterial genes?
Conclusion
The SEAS tool provides reliable pathway mapping results and identifies more organism-specific pathways than existing programs.
Supporting Evidence
- SEAS identified seven significantly enriched pathways in E. coli.
- SEAS achieved 79% precision and 95% coverage for E. coli pathways.
- SEAS identified more organism-specific pathways than KEGG-based tools.
Takeaway
The SEAS program helps scientists understand how genes work together in bacteria by linking them to known biological pathways.
Methodology
The SEAS tool maps genes to pathways using gene ID and orthology mapping, followed by statistical significance assessment.
Limitations
SEAS may have lower coverage compared to KEGG pathways.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website