In Vitro Effect of Fenugreek Extracts on Glucose Uptake and Glycogen Metabolism
Author Information
Author(s): M. AL-HABORI, A. RAMAN, M. J. LAWRENCE, P. SKETT
Primary Institution: King's College London
Hypothesis
The study aims to investigate the mechanisms through which fenugreek extracts affect glucose uptake and glycogen metabolism.
Conclusion
Fenugreek extracts can inhibit glucose absorption in the intestine and affect hepatic glycogen metabolism.
Supporting Evidence
- Fenugreek extracts inhibited glucose uptake at concentrations of 0.33 and 3.3 mg/mL.
- Greatest inhibition of glucose uptake was observed with saponin and aglycone extracts.
- Diosgenin inhibited glucagon-induced glycogen phosphorylase a activity by 20%.
Takeaway
Fenugreek seeds can help lower blood sugar by stopping the body from absorbing too much glucose and affecting how the liver processes sugar.
Methodology
The study used in vitro models with rabbit intestinal brush border membrane vesicles and rat hepatocyte suspensions to test the effects of various fenugreek extracts.
Limitations
The study was conducted in vitro, and results may not directly translate to in vivo effects.
Participant Demographics
The study included Type I and Type II diabetic patients.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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