Angiotensin (1–7) Improves Pancreatic Islet Function in Mice
Author Information
Author(s): Lin Ziwei, Lin Jiaqi, Huang Anqi, Zhang Zixu, Wu Xinyi, Yin Guoshu, Wei Chiju, Xu Wencan
Primary Institution: Shantou University Medical College
Hypothesis
This study aimed to verify the effect of angiotensin (1–7) on improving islet function and explore the signaling pathway involved.
Conclusion
Angiotensin (1–7) could improve glucose and lipid metabolism and islet function by promoting the expression of PDX-1 and GCK genes in the pancreas of db/db mice.
Supporting Evidence
- Angiotensin (1–7) improved glucose and lipid metabolism in db/db mice.
- Angiotensin (1–7) increased the total volume and number of islets as well as the beta-cell ratio and beta-cell mass in db/db mice.
- Angiotensin (1–7) activated the expression of PDX-1 and GCK in the pancreas of db/db mice.
Takeaway
This study found that a substance called angiotensin (1–7) helps mice with diabetes by making their insulin-producing cells work better.
Methodology
Forty-five db/db mice were divided into groups receiving different doses of angiotensin (1–7) for 8 weeks, and their weight, food intake, blood glucose, and islet function were measured.
Limitations
The study did not examine other crucial genes involved in β-cell function and did not investigate downstream signaling pathways of the Ang-(1–7)-Mas axis.
Participant Demographics
Forty-five 6-week-old male db/db mice and seven 7-week-old male db/m mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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