Different types of FC γ -receptors are involved in anti-Lewis Y antibody induced effector functions in vitro
2000
Different types of Fc gamma receptors in antibody effects
publication
Author Information
Author(s): Dettke M, Loibner H
Primary Institution: Clinic for Blood Group Serology and Transfusion Medicine, University Hospital of Vienna, Austria
Hypothesis
Different types of Fc gamma receptors are involved in the effector functions induced by anti-Lewis Y antibodies.
Conclusion
The study found that anti-LeY antibodies induce different immune responses through distinct Fc gamma receptors.
Supporting Evidence
- Anti-LeY antibodies induce both antibody-dependent cellular cytotoxicity and TNF-α release.
- Cytokine release requires a higher concentration of antibodies than cytolysis.
- Cytolysis is triggered by FcγRI, while TNF-α release mainly depends on FcγRII.
Takeaway
This study shows that certain antibodies can trigger immune cells in different ways, depending on the type of receptor they interact with.
Methodology
The study involved mixed cultures of monocytes and breast cancer cells to observe immune responses.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website