Single vs Multiple Fractions of Palliative Radiotherapy for Bone Metastases
Author Information
Author(s): Amouzegar–Hashemi F. MD, Behrouzi H. MD, Kazemian A. MD, Zarpak B. PhD, Haddad P. MD
Primary Institution: Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences
Hypothesis
Is there a difference in pain relief between single-fraction and multiple-fraction palliative radiotherapy for bone metastases?
Conclusion
The study found no significant difference in pain relief between single and multiple fractions of palliative radiotherapy in Iranian patients.
Supporting Evidence
- 71% of patients had a response to treatment, which is similar to international results.
- 14% of patients had complete responses, while 57% had partial responses.
- Age was a significant factor in pain reduction, with younger patients responding better.
Takeaway
Doctors wanted to see if giving one big dose of radiation helps pain just as much as giving smaller doses over time. They found it works about the same.
Methodology
Patients were randomized to receive either 8 Gy in a single fraction or 30 Gy in 10 fractions, with pain assessed before and one month after treatment.
Limitations
Some patients died or did not return for follow-up, reducing the number of evaluable patients.
Participant Demographics
70 patients (63% women; mean age: 51.6 years) with multiple painful uncomplicated bone metastases.
Statistical Information
P-Value
p = 0.01
Statistical Significance
p > 0.1
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