Effects of Potassium Bicarbonate and D-Ribose on Cancer Cell Growth
Author Information
Author(s): Simonetta Croci, Luca Bruni, Simona Bussolati, Marianna Castaldo, Maurizio Dondi
Primary Institution: University of Parma
Hypothesis
The study tests the synergic action of potassium bicarbonate and D-ribose on the proliferation of canine and human cancer cell lines.
Conclusion
The K:D-Rib solution shows a cytostatic effect on cancer cell proliferation, particularly at a concentration of 5 mM.
Supporting Evidence
- The K:D-Rib solution has an antioxidant behavior even at low concentrations.
- At 5 mM concentration, cell growth arrests between 48 h and 72 h.
- Control cells split sixteen times while 5 mM treated cells split eleven times over 48 days.
Takeaway
This study found that a special solution can slow down the growth of cancer cells, which might help in treating cancer.
Methodology
The study used MTT assays and clonogenic assays to evaluate cell proliferation and viability at different concentrations of K:D-Rib.
Limitations
The MTT assay may not reliably indicate cell viability due to interactions with K:D-Rib solutions.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website