β-blockers and metabolic modulation: unraveling the complex interplay with glucose metabolism, inflammation and oxidative stress
2024

How Beta-Blockers Affect Metabolism and Inflammation

publication Evidence: moderate

Author Information

Author(s): Szymon Drygała, Michał Radzikowski, Mateusz Maciejczyk

Primary Institution: Medical University of Bialystok, Bialystok, Poland

Hypothesis

This review aims to report the impact of β-blockers on metabolic modulation based on available literature data.

Conclusion

Certain β-blockers, particularly nebivolol and carvedilol, may have favorable effects on metabolic parameters and glycemic control in patients with diabetes mellitus or cardiometabolic syndrome.

Supporting Evidence

  • Nebivolol and carvedilol may improve insulin sensitivity and lipid metabolism.
  • Vasodilatory β-blockers have potential therapeutic options for patients with metabolic disorders.
  • The influence of β-blockers on glucose metabolism is complex and varies by patient population.

Takeaway

Beta-blockers are medicines that help with heart problems, and some of them can also help people with diabetes by improving how their bodies use sugar.

Methodology

This is a review article summarizing existing literature on the effects of β-blockers on metabolism and inflammation.

Limitations

Many findings were based on animal studies or small human cohorts, which limits the generalizability of the results.

Digital Object Identifier (DOI)

10.3389/fphar.2024.1489657

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