Genetic Factors Linked to Lower Breast Cancer Risk in Indian Women
Author Information
Author(s): Narendra N. Joshi, Mithila D. Kale, Sujata S. Hake, Sadhana Kannan
Primary Institution: Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
Hypothesis
Do TGFβ1 and TGFBR1 gene polymorphisms influence breast cancer risk in Indian women?
Conclusion
The study suggests that specific genetic variants may contribute to a lower risk of breast cancer in western Indian women compared to Parsi women.
Supporting Evidence
- The frequency of the TGFB1*C allele was higher in Maharashtrian women compared to Parsi women.
- Lower incidence rates of breast cancer in Indian women compared to White women were noted.
- Significant protective effects of the TGFB1*29C allele were observed in younger Maharashtrian women.
Takeaway
Some genes can help protect Indian women from getting breast cancer, especially younger ones.
Methodology
A case-control study comparing genetic polymorphisms in breast cancer patients and healthy controls from two distinct communities.
Potential Biases
Potential bias due to the ethnic homogeneity of the study population.
Limitations
The study's power is limited due to the small sample size, which may affect the reliability of the findings.
Participant Demographics
Participants included premenopausal Maharashtrian women and Parsi women, with a mean age of 33.1 years for controls and 39.1 years for patients in the Maharashtrian group.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI 0.25–0.81
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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