Positional Bias of Regulatory Motifs in Mouse Gene Promoters
Author Information
Author(s): Nicolás Bellora, Domènec Farré, M. Alba
Primary Institution: Universitat Pompeu Fabra, Barcelona, Spain
Hypothesis
The study investigates the positional bias of regulatory motifs in mouse gene promoters and their relationship to tissue-specific transcriptional regulation.
Conclusion
Motif positional bias is a significant feature of mammalian proximal promoters, influencing both general and tissue-specific motifs.
Supporting Evidence
- Housekeeping gene promoters have more fixed structures than tissue-specific gene promoters.
- YY1 is a key motif in housekeeping genes but not in tissue-specific genes.
- The study predicts 559 tissue-specific motifs in mouse gene promoters.
Takeaway
This study looks at how the arrangement of DNA motifs in gene promoters affects how genes are turned on or off in different tissues.
Methodology
The study used a systematic search for motifs in 6,372 mouse gene promoter sequences, analyzing their positional bias using the PEAKS program.
Statistical Information
P-Value
p<=0.00001
Statistical Significance
p<=0.00001
Digital Object Identifier (DOI)
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