The Evolution of Androgen Receptors in Fish
Author Information
Author(s): Douard Véronique, Brunet Frédéric, Boussau Bastien, Ahrens-Fath Isabelle, Vlaeminck-Guillem Virginie, Haendler Bernard, Laudet Vincent, Guiguen Yann
Primary Institution: INRA-SCRIBE IFR 140, Campus de Beaulieu, Rennes, France
Hypothesis
The study investigates the fate of the duplicated androgen receptor in fishes and its potential neofunctionalization.
Conclusion
The existence of two distinct androgen receptor duplicates in fish may be linked to specific functional differences related to sex determination.
Supporting Evidence
- AR gene duplication is consistent with an early whole genome duplication event.
- One of the duplicated copies, AR-B, was lost in several basal Clupeocephala.
- Specific mutations in AR-B are correlated with functional differences in sex determination.
Takeaway
Fish have two types of androgen receptors that help them determine their sex, and these receptors have changed over time to help fish adapt.
Methodology
The study involved genomic and syntenic analyses, as well as PCR amplification to investigate androgen receptor duplication and evolution.
Limitations
The study may not account for all fish species and relies on available genomic data, which may not be comprehensive.
Digital Object Identifier (DOI)
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