Second Primary Cancers After Non-Hodgkin's Lymphoma
Author Information
Author(s): Brennan P, Coates M, Armstrong B, Colin D, Boffetta P
Primary Institution: International Agency for Research on Cancer
Hypothesis
Are there common causal agents for second primary neoplasms following non-Hodgkin's lymphoma?
Conclusion
Patients with non-Hodgkin's lymphoma have an increased risk of developing certain second primary cancers, particularly skin melanomas and cancers of the lip and tongue, likely due to sunlight exposure.
Supporting Evidence
- There were 705 second primary neoplasms observed compared to 592.99 expected.
- Excesses of skin melanomas, lip cancer, tongue cancer, and bladder cancer were noted.
- Soft tissue sarcomas and thyroid cancer also showed significant excesses.
- The study suggests sunlight exposure as a shared causal agent for some cancers.
Takeaway
People who had non-Hodgkin's lymphoma are more likely to get other types of cancer, especially skin cancer, possibly because of too much sun.
Methodology
Analysis of data from the New South Wales Central Cancer Registry for patients diagnosed with non-Hodgkin's lymphoma between 1972 and 1995.
Limitations
The study is limited to data from New South Wales and may not be generalizable to other populations.
Participant Demographics
Patients diagnosed with non-Hodgkin's lymphoma in New South Wales, Australia.
Statistical Information
Confidence Interval
95% CI 1.10–1.28
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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