Psoriasis Treatments and Heart Health
Author Information
Author(s): Ji Lixin, Ravi Sowmya, Wright Laura, Nguyen Vi, Wiley Jose, Vukelic Milena, Kim Sangkyu
Primary Institution: Tulane School of Medicine
Hypothesis
Can biologic agents slow the progression of coronary artery plaques in patients with psoriasis?
Conclusion
TNF-α inhibitors are highly effective in reducing atherosclerosis progression in psoriasis patients, improving vascular health markers.
Supporting Evidence
- TNF-α inhibitors significantly improved atherosclerosis markers such as CIMT, aPWV, FAI, and CRP.
- IL-17 inhibitors showed a greater effect in reducing non-calcified plaque burden compared to TNF-α inhibitors.
- Fumaric acid improved cholesterol metabolism.
Takeaway
This study looked at how certain psoriasis treatments can help keep hearts healthy. It found that some medicines work really well to stop heart problems.
Methodology
A systematic review of studies from PubMed, Embase, and Web of Science, focusing on treatments for psoriasis and their effects on atherosclerosis markers.
Potential Biases
Potential confounding effects of concomitant medications and lifestyle factors not consistently accounted for.
Limitations
Heterogeneity of studies, varying metrics for measuring atherosclerosis, and short follow-up durations.
Participant Demographics
Human subjects over 18, with a focus on psoriasis and psoriatic arthritis patients.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website