T-2 Toxin-induced Toxicity in Pregnant Mice and Rats
2008
T-2 Toxin Effects on Pregnant Mice and Rats
publication
Evidence: moderate
Author Information
Author(s): Doi Kunio, Ishigami Noriaki, Sehata Shinya
Primary Institution: Nippon Institute for Biological Science
Hypothesis
How does T-2 toxin affect maternal and fetal health in pregnant mice and rats?
Conclusion
T-2 toxin passes through the placenta and causes apoptosis in both maternal and fetal tissues, leading to various toxic effects.
Supporting Evidence
- T-2 toxin inhibits protein synthesis and induces apoptosis in various cell types.
- T-2 toxin readily crosses the placenta and affects fetal tissues.
- Maternal exposure to T-2 toxin leads to significant toxic effects in both maternal and fetal tissues.
Takeaway
T-2 toxin is a harmful substance that can hurt both pregnant mice and their babies, causing serious health problems.
Methodology
The study reviews existing data on T-2 toxin's effects on pregnant mice and rats, focusing on maternal and fetal toxicities.
Limitations
Limited reports on T-2 toxin exposure in pregnant animals.
Participant Demographics
Pregnant mice and rats.
Digital Object Identifier (DOI)
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