Gut Microbiota and Cognitive Flexibility in Mice
Author Information
Author(s): González Cristian Yuriana, Estrada José Antonio, Oros-Pantoja Rigoberto, Colín-Ferreyra María del Carmen, Benitez-Arciniega Alejandra Donaji, Soto Piña Alexandra Estela, Aguirre-Garrido José Félix
Primary Institution: School of Medicine, Autonomous University of the State of Mexico
Hypothesis
Chronic physical stress and a high-fat diet affect cognitive flexibility and gut microbiota composition in adolescent BALB/c mice.
Conclusion
Chronic physical stress and a high-fat diet impair cognitive flexibility and alter the gut microbiota in adolescent mice.
Supporting Evidence
- Chronic stress and high-fat diets were shown to reduce cognitive flexibility in both male and female mice.
- Significant changes in gut microbiota composition were observed in response to stress and diet.
- Predictive functional analysis indicated alterations in metabolic pathways related to lipid and amino acid metabolism.
Takeaway
This study found that stress and unhealthy eating can make mice less flexible in their thinking and change the bacteria in their guts.
Methodology
The study involved 47 BALB/c mice subjected to chronic physical stress and a high-fat diet, with cognitive flexibility assessed using the Attentional Set-Shifting Test.
Limitations
The study did not measure plasma concentrations of lipids, enzymes, or neurohormones that could relate to the microbiota-gut-brain axis.
Participant Demographics
30 male and 17 female BALB/c mice, 10 weeks of age.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website