Prognostic significance of angiogenesis in human pancreatic cancer
1999
Angiogenesis and Prognosis in Pancreatic Cancer
Sample size: 40
publication
Evidence: moderate
Author Information
Author(s): Ikeda N, Adachi M, Taki T, Huang C, Hashida H, Takabayashi A, Sho M, Nakajima Y, Kanehiro H, Hisanaga M, Nakano H, Miyake M
Primary Institution: Kitano Hospital, Tazuke Kofukai Medical Research Institute
Hypothesis
Are angiogenic factors clinically relevant to human pancreatic cancers?
Conclusion
Higher levels of angiogenic factors are associated with shorter survival times in pancreatic cancer patients.
Supporting Evidence
- 75% of pancreatic cancers were PD-ECGF-positive.
- 67.5% of pancreatic cancers were VEGF-positive.
- Tumors with both PD-ECGF and VEGF positive expression had a higher intratumoral microvessel density.
- Median survival time was shorter for patients with positive PD-ECGF expression.
- Median survival time was shorter for patients with positive VEGF expression.
- IMD and VEGF expression were independent prognostic factors.
Takeaway
This study found that more blood vessels in pancreatic tumors mean patients might not live as long.
Methodology
The study used immunohistochemistry and reverse transcriptase-PCR to evaluate angiogenic factors in pancreatic cancer.
Statistical Information
P-Value
P = 0.006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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