Low-Protein Diet in Nursing Mothers Affects Glucose and Insulin in Male Rats
Author Information
Author(s): de Freitas Mathias Paulo Cezar, Dantas Rodrigues Aline Milena, Lisboa Patrícia Cristina, Miranda Rosiane Aparecida, Malta Ananda, Ribeiro Tatiane Aparecida, Barella Luiz Felipe, Dias Ginislene, Lima Thalyne Aparecida Leite, Gomes Rodrigo Mello, de Moura Egberto Gaspar, de Oliveira Júlio Cezar
Primary Institution: State University of Maringa, Federal University of Mato Grosso, State University of Rio de Janeiro, Federal University of Goiás
Hypothesis
Do male rats whose mothers are on a low-protein diet during nursing have impaired glucose-insulin homeostasis and pancreatic islet function?
Conclusion
Male rats whose mothers were on a low-protein diet during nursing show glucose-insulin dyshomeostasis and pancreatic islet dysfunction.
Supporting Evidence
- LP rats showed reduced body weight and adiposity index compared to NP rats.
- Chronic dexamethasone treatment induced hyperglycemia and hyperinsulinemia in NP rats.
- LP rats exhibited impaired insulin secretion under metabolic stress.
Takeaway
If a mother rat doesn't eat enough protein while feeding her babies, those baby rats might have trouble with sugar and insulin when they grow up.
Methodology
The study involved feeding lactating dams a low-protein or normal-protein diet and assessing the metabolic responses of their male offspring at 90 days of age.
Potential Biases
Potential bias due to the specific focus on male rats and the exclusion of female rats.
Limitations
The study did not measure ACTH receptors in the adrenal cortex.
Participant Demographics
Male Wistar rats from mothers fed either a low-protein or normal-protein diet during lactation.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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