Alcohol and Colorectal Cancer: Global Burden and Trends
Author Information
Author(s): Yao Jinfeng, Chen Guo
Primary Institution: Department of Oncology, Shuguang Anhui Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Hypothesis
This study aims to quantify the global, regional, and national burden of alcohol-related colorectal cancer between 1990 and 2021.
Conclusion
The study highlights that alcohol is a significant risk factor for colorectal cancer and emphasizes the need for improved prevention and treatment strategies.
Supporting Evidence
- Alcohol consumption is a major risk factor for colorectal cancer.
- The number of alcohol-related colorectal cancer deaths increased from 33,239 in 1990 to 56,102 in 2021.
- Men are more affected by alcohol-related colorectal cancer than women, with a burden four to five times higher.
- Age-standardized rates of deaths and DALYs generally increased with age.
- High SDI regions show the highest burden of alcohol-related colorectal cancer.
Takeaway
Drinking alcohol can lead to a higher chance of getting colorectal cancer, and this problem is getting worse around the world.
Methodology
The study analyzed mortality and disability-adjusted life years (DALYs) from 1990 to 2021 using data from the Global Burden of Disease study and employed linear regression and Bayesian models for trend analysis.
Potential Biases
Potential biases may arise from reliance on civil registration and vital statistics, which can vary in completeness across regions.
Limitations
The study's accuracy may be affected by incomplete data from health systems and the exclusion of other significant risk factors for colorectal cancer.
Participant Demographics
The burden of disease is significantly higher in males and older age groups.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% UI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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