Per vaginal bleeding-an important but ignored feature of dengue
2024

Per vaginal bleeding in dengue

Sample size: 288 publication Evidence: moderate

Author Information

Author(s): Wijewickrama Ananda, Kuruppu Heshan, Idampitiya Damayanthi, Wickramanayake Rivindu, Kottahachchi Anagi, Jayamali Jeewantha, Chathurangika Padukkage Harshani, Senatilleke Nushara, Warnakulasuriya Navanjana, Jeewandara Chandima, Malavige Gathsaurie Neelika

Primary Institution: National Institute of Infectious Diseases, Angoda, Sri Lanka

Hypothesis

What is the frequency and impact of per vaginal bleeding in women with dengue?

Conclusion

Per vaginal bleeding is associated with worse disease outcomes in women with dengue.

Supporting Evidence

  • 28 out of 288 women reported per vaginal bleeding.
  • 42.85% of those with PV bleeding developed dengue hemorrhagic fever.
  • Women with PV bleeding were more likely to experience abdominal pain and vomiting.
  • Those with PV bleeding had a higher likelihood of requiring blood transfusions.

Takeaway

This study looked at women with dengue and found that those who had vaginal bleeding were more likely to get sicker.

Methodology

288 adult female patients were recruited and monitored for clinical features and laboratory investigations during their hospital stay.

Potential Biases

Potential biases in patient selection and reporting of symptoms.

Limitations

The study may not fully capture all complications related to PV bleeding due to limited data.

Participant Demographics

Adult female patients aged over 18 years.

Statistical Information

P-Value

0.06

Confidence Interval

95% CI 0.98 to 5.1

Statistical Significance

p=0.06

Digital Object Identifier (DOI)

10.1101/2024.12.23.24319534

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