CAIX and Chemotherapy Resistance in Basal-like Breast Tumors
Author Information
Author(s): Tan E Y, Yan M, Campo L, Han C, Takano E, Turley H, Candiloro I, Pezzella F, Gatter K C, Millar E K A, O'Toole S A, McNeil C M, Crea P, Segara D, Sutherland R L, Harris A L, Fox S B
Primary Institution: Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
Hypothesis
The aggressive phenotype of basal-like breast tumors is due to an intrinsically elevated hypoxic response.
Conclusion
Basal-like breast tumors are associated with increased CAIX expression, which correlates with worse outcomes and chemotherapy resistance.
Supporting Evidence
- Basal-like tumors account for 14% of the studied breast tumors.
- These tumors showed a significantly worse disease-free survival compared to luminal tumors.
- CAIX expression was positively correlated with tumor size and grade.
Takeaway
Some breast tumors are more aggressive and harder to treat because they don't get enough oxygen, and this can make them resistant to chemotherapy.
Methodology
Tumor samples from 621 patients were analyzed for hypoxia markers and correlated with clinical outcomes.
Potential Biases
Potential bias in patient selection and tumor classification.
Limitations
Data was not available for all patients, and the study focused on specific tumor markers.
Participant Demographics
Median age of participants was 55 years, with a range from 24 to 87 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 3.86–20.29
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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