Major hepatic resection may suppress the growth of tumours remaining in the residual liver
2000
Effects of Hepatectomy on Tumor Growth in the Liver
publication
Evidence: moderate
Author Information
Author(s): Yokoyama H, Goto S, Chen C-L, Pan T-L, Kawano K, Kitano S
Primary Institution: Chang Gung Memorial Hospital
Hypothesis
How does hepatectomy affect the growth of hepatic tumors in the remaining liver?
Conclusion
Major hepatic resection may lead to increased apoptosis of remaining hepatic tumors.
Supporting Evidence
- After 30% hepatectomy, tumor weight in the remaining liver was significantly greater than in sham operations.
- After 60% hepatectomy, tumor weight in the remaining liver was significantly lower than in sham animals.
- TUNEL positive tumor cells were significantly increased in the 60% hepatectomy group compared to others.
- mRNA expression of TGF-β1, TNF-α, and Fas was higher in the 60% hepatectomy group than in the 30% group.
- Plasma levels of TGF-β1 were inversely correlated with intra-hepatic tumor weights.
Takeaway
When doctors remove part of the liver, it can actually help stop the growth of leftover tumors in the liver.
Methodology
An intra-hepatic tumor implantation model in rats was used to investigate the effects of hepatectomy on tumor growth.
Participant Demographics
Rats were used in the study.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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